Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 20/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.46 |
| ▸ | CASP1 | P29466 | 9/20 | 0.46 |
| ▸ | CASP7 | P55210 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 7/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17813476 | 0.74 | CDK4 (0.41) | HSD17B10HPGD | |
| SCHEMBL17813499 | 0.70 | CYP1A2 (0.63) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL17813498 | 0.69 | CDK4 (0.33) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL17813507 | 0.69 | CYP1A2 (0.53) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL22054402 | 0.68 | CCNB2 (0.33) | ALDH1A1HSD17B10HPGD | |
| SCHEMBL17813502 | 0.68 | CYP1A2 (0.44) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL5448218 | 0.67 | ALDH1A1 (0.53) | ALDH1A1HSD17B10CASP1CASP7HPGD | |
| SCHEMBL17813472 | 0.67 | CYP1A2 (0.36) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL5445042 | 0.66 | KDM4E (0.56) | ALDH1A1HSD17B10CASP1CASP7HPGD | |
| SCHEMBL17813552 | 0.66 | HSD17B10 (0.32) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170216301-A1 | NOVEL BICYCLIC BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD. | 2017-08-03 | — | — | US | disclosed |
| US-9663520-B2 | Bicyclic bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2017-05-30 | — | — | US | disclosed |
| US-20160159801-A1 | NOVEL BICYCLIC BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS CORP. | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170216301-A1 | NOVEL BICYCLIC BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD2 | CYP1A2 4563/4885ALDH1A1 4568/4885HSD17B10 2464/4885 |
| US-20160159801-A1 | NOVEL BICYCLIC BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD2 | CYP1A2 4563/4885ALDH1A1 4568/4885HSD17B10 2464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.