SCHEMBL1781352

SCHEMBL1781352

C[C@@]12CCC[C@H]1[C@@H]1CCC3CC(=O)C=C[C@]3(C)[C@@H]1CC2

nearest known ligand 0.62

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MBOAT4 Q96T53 3/20 0.62
CYP19A1 P11511 3/20 0.49
CDK5 Q00535 1/20 0.44
CDK5R1 Q15078 1/20 0.44
NR1I3 Q14994 1/20 0.44
GRIN1 Q05586 6/20 0.44
GRIN2B Q13224 6/20 0.44
SHBG P04278 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL219127 1.00 MBOAT4 (0.62) MBOAT4CYP19A1CDK5CDK5R1NR1I3
SCHEMBL21176005 1.00 MBOAT4 (0.62) MBOAT4CYP19A1CDK5CDK5R1NR1I3
SCHEMBL29688566 1.00 MBOAT4 (0.62) MBOAT4CYP19A1CDK5CDK5R1NR1I3
SCHEMBL4802159 1.00 MBOAT4 (0.62) MBOAT4CYP19A1CDK5CDK5R1NR1I3
SCHEMBL3268576 0.81 MBOAT4 (0.53) MBOAT4CYP19A1CDK5CDK5R1NR1I3
SCHEMBL1788661 0.80 MBOAT4 (0.46) MBOAT4CYP19A1GRIN1GRIN2BSHBG
SCHEMBL2186022 0.79 CYP19A1 (0.55) CYP19A1SHBG
SCHEMBL1287860 0.79 CYP19A1 (0.55) CYP19A1SHBG
SCHEMBL1287861 0.79 CYP19A1 (0.55) CYP19A1SHBG
SCHEMBL9512557 0.79 CYP19A1 (0.55) CYP19A1SHBG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1467739-A4 17-HYDROXY-4-AZA-ANDROSTAN-3-ONES AS ANDROGEN RECEPTOR MODULATORS MERCK & CO INC (US) 2008-01-09 EP claimed
EP-1467739-A2 17-HYDROXY-4-AZA-ANDROSTAN-3-ONES AS ANDROGEN RECEPTOR MODULATORS Merck & Co., Inc. (US) 2004-10-20 EP claimed
EP-1463483-A1 NEW COMPOSITION Ponsus Pharma AB (SE) 2004-10-06 EP claimed
WO-2003059293-A2 17-HYDROXY-4-AZA-ANDROSTAN-3-ONES AS ANDROGEN RECEPTOR MODULATORS MERCK & CO., INC. (US) 2003-07-24 WO claimed
WO-2003055454-A1 NEW COMPOSITION PONSUS PHARMA AB (SE) 2003-07-10 WO claimed
EP-1322663-A1 NOVEL POLYMORPHIC FORM OF 17-BETA-(N-TER.BUTYL CARBAMOYL)-4-AZA-5- G(A)-ANDROST-1-EN-3-ONE AND A PROCESS FOR PREPARING IT Dr. Reddy's Laboratories Ltd. (IN) 2003-07-02 EP claimed
WO-2002020553-A1 NOVEL POLYMORPHIC FORM OF 17-β-(N-TER.BUTYL CARBAMOYL)-4-AZA-5-α-ANDROST-1-EN-3-ONE AND A PROCESS FOR PREPARING IT DR. REDDY'S LABORATORIES LTD. (IN) 2002-03-14 WO claimed
EP-0468012-B1 17$g(b)-SUBSTITUTED-4-AZA-5$g(a)-ANDROSTAN-3-ONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION PHARMACIA SPA (IT) 1995-09-20 EP claimed
EP-0649431-A4 17-AMINO SUBSTITUTED 4-AZASTEROID 5-G(A)-REDUCTASE INHIBITORS. 1995-05-03 EP claimed
EP-0649431-A1 17-AMINO SUBSTITUTED 4-AZASTEROID 5$g(a)-REDUCTASE INHIBITORS MERCK & CO. INC. (US) 1995-04-26 EP claimed
WO-1993023038-A1 17-AMINO SUBSTITUTED 4-AZASTEROID 5α-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO claimed
WO-1991012261-A1 17β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION FARMITALIA CARLO ERBA S.R.L. (IT) 1991-08-22 WO claimed
EP-0073026-B1 17,17-BIS(SUBSTITUTED THIO)-3-KETOANDROSTENES AND PHARMACEUTICAL COMPOSITIONS E.R. Squibb & Sons, Inc. (US) 1986-03-19 EP claimed
EP-0073026-A1 17,17-Bis(substituted thio)-3-ketoandrostenes and pharmaceutical compositions E.R. Squibb & Sons, Inc. (US) 1983-03-02 EP claimed
US-4361559-A TOPICAL ADMINISTRATION FOR SKIN DISORDERS OF ASTHMA E. R. SQUIBB & SONS, INC. (US) 1982-11-30 US claimed
CN-111356449-B Dutasteride solid dispersion, preparation method thereof and pharmaceutical composition containing same 韩国普莱姆制药株式会社 2022-12-02 CN disclosed
CN-107206010-B C-19 steroids to inhibit neovascularization 库拉迪斯有限公司 2021-12-21 CN disclosed
EP-0100566-A1 Novel 19-thio-androstane derivatives AKZO N.V. (NL) 1984-02-15 EP disclosed
EP-0073026-A1 17,17-Bis(substituted thio)-3-ketoandrostenes and pharmaceutical compositions E.R. Squibb & Sons, Inc. (US) 1983-03-02 EP disclosed
US-4361559-A TOPICAL ADMINISTRATION FOR SKIN DISORDERS OF ASTHMA E. R. SQUIBB & SONS, INC. (US) 1982-11-30 US disclosed