MBOAT4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5229324	0.63	20/20
SCHEMBL3002411	0.53	20/20
SCHEMBL5228820	0.51	20/20
SCHEMBL5228809	0.50	20/20
SCHEMBL230425	0.52	19/20
SCHEMBL304348	0.50	19/20
SCHEMBL5102818	0.50	19/20
SCHEMBL5225182	0.50	19/20
SCHEMBL5228485	0.50	19/20
SCHEMBL5226752	0.67	18/20
SCHEMBL5799693	0.51	18/20
SCHEMBL5227025	0.50	18/20
SCHEMBL1930249	0.41	18/20
SCHEMBL5228618	0.60	17/20
SCHEMBL5229986	0.56	16/20
SCHEMBL302642	0.50	16/20
SCHEMBL609328	0.36	16/20
SCHEMBL4879793	0.45	13/20
SCHEMBL4883759	0.43	11/20
SCHEMBL4425907	0.44	10/20

Clinical trials — most relevant to MBOAT4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH)	PHASE4	COMPLETED
Effects of Omega-3 Fatty Acids on the Human Gene Expression	PHASE4	COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder	PHASE1/PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
Atomoxetine in Melanocortin Obesity Syndrome	PHASE2	NOT_YET_RECRUITING
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes	nan	COMPLETED
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
Association Between the Change of the Genes With Hormones and Food Consumption of Obese	nan	COMPLETED
Effect of Cocoa Polyphenols Supplementation on Cardiovascular Risk of Postmenopausal Women	nan	UNKNOWN
Effects of a 12-week Combined Exercise Program on Ghrelins in Obese Adolescent Girls	nan	COMPLETED
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism	nan	COMPLETED
Effects of Lipids on Gastric Emptying, Satiety Hormones, and Appetite in Severe Overweight	nan	COMPLETED
Effect of Molecular Hydrogen in Patients With NAFLD	nan	COMPLETED
Growth Hormone Signaling in Vivo in Humans	nan	COMPLETED
The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Rare Obesity Cohorts With Food Behavioral Disorders : Better Diagnosis for Better Treatment	nan	RECRUITING
Acylated Ghrelin Response to Acute Exercise in Obesity	nan	COMPLETED
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise	nan	COMPLETED
Brain-Derived Neurotrophic Factor in Obesity and Brain Function	nan	COMPLETED
Gene Expression and Inflammation in Overweight Subjects	nan	COMPLETED
Group Lifestyle Intervention for People With New Onset Type 2 Diabetes.	nan	COMPLETED
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
Effects of Fish Oils on Inflammation and Insulin Resistance	nan	COMPLETED
Genetic Determinants and Clinical Consequences of Early-onset Severe Obesity	nan	UNKNOWN
The Effect of Dietary Fat Load and Physical Exercise on the Flexibility and Partitioning of Ectopic Lipids.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MBOAT4 binder may also engage these)

Protein	Name	Similarity
B1Q005	—	0.999	B1Q005 →
P0C7A3	—	0.999	P0C7A3 →
PORCN	Protein-serine O-palmitoleoyltransferase porcupine	0.967	landscape →
Q9JJJ7	—	0.963	Q9JJJ7 →
Q9HCP6	—	0.963	Q9HCP6 →
B1Q006	—	0.961	B1Q006 →
SOAT2	Sterol O-acyltransferase 2	0.957	landscape →
Q9D1G3	—	0.956	Q9D1G3 →
Q8VC65	—	0.955	Q8VC65 →
O77759	—	0.954	O77759 →
Q6NSQ9	—	0.954	Q6NSQ9 →
Q7TQM4	—	0.953	Q7TQM4 →
Q6MG14	—	0.952	Q6MG14 →
A1A5Z0	—	0.952	A1A5Z0 →
O88908	—	0.952	O88908 →
Q7SZQ0	—	0.951	Q7SZQ0 →
Q9BUM1	—	0.950	Q9BUM1 →
Q7TPN3	—	0.950	Q7TPN3 →
Q641Y9	—	0.950	Q641Y9 →
Q6PJN8	—	0.950	Q6PJN8 →
A0A8C2M425	—	0.950	A0A8C2M425 →
Q148G2	—	0.949	Q148G2 →
Q9NUD9	—	0.949	Q9NUD9 →
Q5KR61	—	0.949	Q5KR61 →
Q9H6D3	—	0.948	Q9H6D3 →
Q8IUH8	—	0.948	Q8IUH8 →
Q96CP7	—	0.947	Q96CP7 →
Q5U4T9	—	0.947	Q5U4T9 →
Q49LS0	—	0.947	Q49LS0 →
Q8BPS4	—	0.947	Q8BPS4 →