Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 10/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.46 |
| ▸ | CCNC | P24863 | 4/20 | 0.43 |
| ▸ | CDK8 | P49336 | 4/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17814108 | 0.91 | CYP11B1 (0.49) | CYP11B1CYP11B2CCNCCDK8PDE3B | |
| SCHEMBL21105188 | 0.87 | CCNC (0.46) | CYP11B1CYP11B2CCNCCDK8PDE3B | |
| SCHEMBL17814146 | 0.85 | CYP11B1 (0.49) | CYP11B1CYP11B2CCNCCDK8BRD4 | |
| SCHEMBL17814163 | 0.85 | CCNC (0.47) | CYP11B1CYP11B2CCNCCDK8SCD5 | |
| SCHEMBL21105098 | 0.84 | CCNC (0.42) | CYP11B1CYP11B2CCNCCDK8PDE3B | |
| SCHEMBL17814142 | 0.83 | CYP11B2 (0.50) | CYP11B1CYP11B2CCNCCDK8 | |
| SCHEMBL21105062 | 0.83 | CCNC (0.41) | CYP11B1CYP11B2CCNCCDK8PDE3B | |
| SCHEMBL17814141 | 0.82 | CYP11B2 (0.49) | CYP11B1CYP11B2CCNCCDK8 | |
| SCHEMBL17802108 | 0.82 | CCNC (0.45) | CYP11B1CYP11B2CCNCCDK8PDE3B | |
| SCHEMBL17802107 | 0.81 | CDK8 (0.43) | CYP11B1CYP11B2CCNCCDK8PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227300-B1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-06-19 | — | — | EP | disclosed |
| EP-3227300-B1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-06-19 | — | — | EP | disclosed |
| US-9890171-B2 | Aldosterone synthase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-02-13 | — | — | US | disclosed |
| US-9890171-B2 | Aldosterone synthase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-02-13 | — | — | US | disclosed |
| US-20170267688-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-09-21 | — | — | US | disclosed |
| US-20170267688-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-09-21 | — | — | US | disclosed |
| WO-2016089800-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267688-A1 | ALDOSTERONE SYNTHASE INHIBITORS | CYP11B1, CYP21A2, CYP11B2 | CYP11B1 1/4885CYP11B2 3/4885CCNC 2192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.