SCHEMBL1781557

SCHEMBL1781557

N#Cc1ccccc1NN

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.52
TSHR P16473 3/20 0.52
HPGD P15428 2/20 0.52
HSD17B10 Q99714 1/20 0.52
GAA P10253 5/20 0.47
L3MBTL1 Q9Y468 2/20 0.44
ALDH1A1 P00352 2/20 0.42
LMNA P02545 2/20 0.42
GLA P06280 1/20 0.42
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
CYP1A2 P05177 2/20 0.41
PDK1 Q15118 1/20 0.41
PDK2 Q15119 1/20 0.41
PDK3 Q15120 1/20 0.41
PDK4 Q16654 1/20 0.41
TAS1R3 Q7RTX0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL20984459 0.98 KDM4E (0.50) KDM4ETSHRHPGDHSD17B10GAA
Hydrochloric Acid SCHEMBL1821629 0.98 KDM4E (0.50) KDM4ETSHRHPGDHSD17B10GAA
Hydrochloric Acid SCHEMBL31549660 0.98 KDM4E (0.50) KDM4ETSHRHPGDHSD17B10GAA
Oxalic Acid SCHEMBL20984729 0.88 GAA (0.56) KDM4ETSHRHPGDHSD17B10GAA
Phosphoric Acid SCHEMBL20984128 0.88 GAA (0.47) KDM4ETSHRHPGDHSD17B10GAA
Sulfuric Acid SCHEMBL20984556 0.88 CA12 (0.49) KDM4ETSHRHPGDHSD17B10GAA
Oxalic Acid SCHEMBL20984731 0.88 GAA (0.56) KDM4ETSHRHPGDHSD17B10GAA
Nitric Acid SCHEMBL20984394 0.85 GAA (0.45) KDM4ETSHRHPGDHSD17B10GAA
SCHEMBL395135 0.80 KDM4E (0.55) KDM4ETSHRHPGDHSD17B10GAA
SCHEMBL30804597 0.80 KDM4E (0.55) KDM4ETSHRHPGDHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110003160-A A kind of Osthole hydrazone class/acylhydrazone class/sulphur acylhydrazone and preparation method thereof and application 贵州中医药大学 2019-07-12 CN claimed
CN-106995433-A A kind of Ai Le replaces the preparation method of Buddhist nun 湖南博奥德生物医药技术开发有限公司 2017-08-01 CN claimed
CN-104610002-B A kind of method of aryl hydrazine synthesis symmetry biphenyl 绍兴文理学院 2016-08-24 CN claimed
CN-104610002-A Method for synthesizing symmetrical biphenyl from aromatic hydrazine UNIV SHAOXING 2015-05-13 CN claimed
CN-101830831-B Method for preparing ortho-diazanyl benzonitrile QINGDAO HUANGHAI PHARMACEUTICAL CO LTD 2013-06-12 CN claimed
CN-101830831-A Method for preparing ortho-diazanyl benzonitrile QINGDAO HUANGHAI PHARMACEUTICAL CO LTD 2010-09-15 CN claimed
JP-60181069-A None JP disclosed
JP-55122752-A None JP disclosed
US-20250179079-A1 HEXAHYDROPYRIDO[4,3-B]INDOLYL KETONE DERIVATIVES USEFUL AS CGAS MODULATORS VENTUS THERAPEUTICS U.S., INC. (US) 2025-06-05 US disclosed
CN-119768407-A Protein phosphatase agonist and application thereof 南京中瑞药业有限公司 2025-04-04 CN disclosed
WO-2024050800-A1 PROTEIN PHOSPHATASE AGONIST AND USE 南京中瑞药业有限公司 2024-03-14 WO disclosed
EP-4308566-A1 PURINE DERIVATIVES AS ANTICANCER AGENTS Tango Therapeutics, Inc. (US) 2024-01-24 EP disclosed
WO-2023183886-A2 COMPOSITIONS FOR AND METHODS OF MODULATING RNA STABILITY DUKE UNIVERSITY (US) 2023-09-28 WO disclosed
US-20020155952-A1 Unidirectionally see-through decorative films FURUKAWA KEN-ICHI (JP) 2002-10-24 US disclosed
US-5789341-A Method for fabricating an imaged film FURUKAWA KENICHI (JP) 1998-08-04 US disclosed
JP-S60181069-A PRODUCTION OF 2,3,3-TRIMETHYLCYANOINDOLENINE MITSUBISHI PAPER MILLS LTD 1985-09-14 JP disclosed
JP-S55122752-A CYANOPHENYLHYDRAZONE COMPOUND KURARAY CO LTD 1980-09-20 JP disclosed
US-3979412-A Process for producing 3-anilino-5-pyrazolones FUJI PHOTO FILM CO., LTD. (JA) 1976-09-07 US disclosed
US-3935183-A WATER INSOLUBLE DYE IMPERIAL CHEMICAL INDUSTRIES LIMITED (EN) 1976-01-27 US disclosed
US-3933874-A Method for preparing of β-anilino-β-hydrazinoacrylates FUJI PHOTO FILM CO., LTD. (JA) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179079-A1 HEXAHYDROPYRIDO[4,3-B]INDOLYL KETONE DERIVATIVES USEFUL AS CGAS MODULATORS CGAS, XDH, NPY1R KDM4E 1682/4885TSHR 2499/4885HPGD 597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.