Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 16/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | STAT6 | P42226 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20699254 | 0.94 | PKM (0.62) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL17815568 | 0.91 | PKM (0.62) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL19727234 | 0.86 | PKM (0.64) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL17815767 | 0.86 | PKM (0.56) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL20699104 | 0.85 | PKM (0.61) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL20699105 | 0.84 | PKM (0.58) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL17815570 | 0.84 | PKM (0.60) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL17815653 | 0.84 | PKM (0.70) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL20716200 | 0.83 | PKM (0.59) | PKMALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL20716287 | 0.83 | PKM (0.58) | PKMALDH1A1LMNATP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981990-B2 | Melampomagnolide B dimers | BIOVENTURES, LLC (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981990-B2 | Melampomagnolide B dimers | BIOVENTURES, LLC (US) | 2018-05-29 | — | — | US | disclosed |
| WO-2016090166-A1 | MELAMPOMAGNOLIDE B DIMERS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2016-06-09 | — | — | WO | disclosed |