Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.77 |
| ▸ | EGFR | P00533 | 2/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | TEC | P42680 | 1/20 | 0.55 |
| ▸ | BMX | P51813 | 1/20 | 0.55 |
| ▸ | CD69 | Q07108 | 1/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.55 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.55 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18877721 | 0.95 | BTK (0.86) | BTKEGFRKCNH2TECBMX | |
| SCHEMBL14228143 | 0.95 | BTK (0.86) | BTKEGFRKCNH2TECBMX | |
| SCHEMBL21386782 | 0.91 | BTK (0.67) | BTKEGFRKCNH2TECBMX | |
| SCHEMBL17703357 | 0.89 | BTK (0.65) | BTKEGFRKCNH2TECBMX | |
| SCHEMBL20881698 | 0.88 | BTK (0.66) | BTKEGFRKCNH2TECBMX | |
| SCHEMBL14228310 | 0.88 | BTK (0.60) | BTKEGFRITK | |
| SCHEMBL17816354 | 0.87 | BTK (0.61) | BTKEGFRKCNH2TECBMX | |
| SCHEMBL19533436 | 0.87 | BTK (1.00) | BTKEGFRKCNH2TECBMX | |
| SCHEMBL19533419 | 0.87 | BTK (1.00) | BTKEGFRKCNH2TECBMX | |
| SCHEMBL21386777 | 0.86 | BTK (0.75) | BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016090021-A1 | METHODS OF TREATING FIBROSIS | PHARMACYCLICS LLC (US) | 2016-06-09 | — | — | WO | disclosed |