⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419892 | 0.72 | — | — | |
| SCHEMBL17816397 | 0.70 | — | — | |
| SCHEMBL7216267 | 0.70 | — | — | |
| SCHEMBL17816405 | 0.67 | — | — | |
| SCHEMBL19485348 | 0.67 | — | — | |
| SCHEMBL7707731 | 0.65 | — | — | |
| SCHEMBL6293455 | 0.64 | CHRNB4 (0.34) | — | |
| SCHEMBL468058 | 0.64 | TSHR (0.37) | — | |
| SCHEMBL1268596 | 0.64 | — | — | |
| SCHEMBL17800693 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4648853-A1 | TARGETED DEGRADATION OF VAV1 | Monte Rosa Therapeutics AG (CH) | 2025-11-19 | — | — | EP | disclosed |
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |
| US-9862732-B2 | Regioselective 1,2-dearomatization of functionalized azines by organolanthanide catalysts | NORTHWESTERN UNIVERSITY (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160159825-A1 | Regioselective 1,2-Dearomatization of Functionalized Azines by Organolanthanide Catalysts | NATIONAL SCIENCE FOUNDATION | 2016-06-09 | — | — | US | disclosed |