Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 14/20 | 0.72 |
| ▸ | KCNK9 | Q9NPC2 | 10/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13400497 | 0.90 | KCNK3 (0.56) | KCNK3KCNK9KCNH2MEN1KMT2A | |
| SCHEMBL3838614 | 0.90 | HDAC1 (0.66) | KCNK3KCNK9KCNH2MEN1KMT2A | |
| SCHEMBL17818378 | 0.87 | NPC1 (0.56) | KCNK3KCNK9KCNH2MEN1KMT2A | |
| SCHEMBL15907199 | 0.87 | HDAC3 (0.60) | KCNK3KCNK9KCNH2MEN1KMT2A | |
| SCHEMBL13132905 | 0.86 | GPR17 (0.58) | KCNK3KCNK9KCNH2MEN1KMT2A | |
| SCHEMBL4252916 | 0.86 | KCNK3 (0.72) | KCNK3KCNK9KCNH2MEN1KMT2A | |
| SCHEMBL5612900 | 0.85 | KCNK3 (0.69) | KCNK3KCNK9MEN1KMT2APOLB | |
| SCHEMBL22627078 | 0.85 | MEN1 (0.61) | KCNK3KCNK9MEN1KMT2ARXFP1 | |
| SCHEMBL4253897 | 0.85 | KCNK3 (0.93) | KCNK3KCNK9KCNH2MEN1KMT2A | |
| SCHEMBL13400494 | 0.84 | HDAC3 (0.55) | KCNK3KCNK9KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297683-B1 | IDENTIFIABLE CHEMICAL PRODUCT | JOHNSON MATTHEY PLC (GB) | 2022-03-23 | — | — | EP | disclosed |
| US-11141385-B2 | Sulfur (VI) fluoride compounds and methods for the preparation thereof | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-10-12 | — | — | US | disclosed |
| US-20180155274-A1 | IDENTIFIABLE CHEMICAL PRODUCT | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2018-06-07 | — | — | US | disclosed |
| US-20180155274-A1 | IDENTIFIABLE CHEMICAL PRODUCT | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2018-06-07 | — | — | US | disclosed |
| US-20180155274-A1 | IDENTIFIABLE CHEMICAL PRODUCT | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2018-06-07 | — | — | US | disclosed |
| EP-3297683-A1 | IDENTIFIABLE CHEMICAL PRODUCT | Johnson Matthey Public Limited Company (GB) | 2018-03-28 | — | — | EP | disclosed |
| CN-105431436-B | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | 内尔维阿诺医学科学有限公司 | 2017-11-28 | — | — | CN | disclosed |
| EP-2997030-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2017-08-09 | — | — | EP | disclosed |
| US-9682083-B2 | Pyrrolo[2,3-D]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-06-20 | — | — | US | disclosed |
| WO-2016185177-A1 | IDENTIFIABLE CHEMICAL PRODUCT | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2016-11-24 | — | — | WO | disclosed |
| US-20160166575-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-06-16 | — | — | US | disclosed |
| CN-105431436-A | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2016-03-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166575-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | RET, DCK, PRKD2 | KCNK3 3041/4885KCNK9 3599/4885KCNH2 4165/4885 |
| US-20180155274-A1 | IDENTIFIABLE CHEMICAL PRODUCT | MYADM, B2M, HLA-C | KCNK3 1826/4885KCNK9 2163/4885KCNH2 778/4885 |
| US-11141385-B2 | Sulfur (VI) fluoride compounds and methods for the preparation thereof | CYP2F1, CYP2S1, NAF1 | KCNK3 2551/4885KCNK9 1758/4885KCNH2 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.