Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 18/20 | 0.55 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.44 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.44 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15059805 | 0.89 | BUB1 (0.69) | BUB1 | |
| SCHEMBL16178608 | 0.83 | BUB1 (0.66) | BUB1 | |
| SCHEMBL15055820 | 0.83 | BUB1 (0.73) | BUB1 | |
| SCHEMBL17508608 | 0.82 | BUB1 (0.80) | BUB1 | |
| SCHEMBL15056247 | 0.82 | BUB1 (0.73) | BUB1 | |
| SCHEMBL18887524 | 0.81 | BUB1 (0.59) | BUB1 | |
| SCHEMBL16324219 | 0.81 | GUCY1B2 (0.45) | BUB1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL15075373 | 0.79 | GUCY1B2 (0.53) | BUB1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL16178664 | 0.78 | BUB1 (0.66) | BUB1 | |
| SCHEMBL16806829 | 0.75 | GUCY1B2 (0.51) | BUB1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168130-A1 | HETEROARYL SUBSTITUTED PYRAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-16 | — | — | US | claimed |
| US-20160168130-A1 | HETEROARYL SUBSTITUTED PYRAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-16 | — | — | US | disclosed |
| US-20160168130-A1 | HETEROARYL SUBSTITUTED PYRAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-16 | — | — | US | disclosed |
| US-20160168130-A1 | HETEROARYL SUBSTITUTED PYRAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168130-A1 | HETEROARYL SUBSTITUTED PYRAZOLES | BUB1, BUB1B, BUB3 | BUB1 1/4885GUCY1B2 4070/4885GUCY1A2 4046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.