Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.55 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 12/20 | 0.42 |
| ▸ | JAK1 | P23458 | 7/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246001 | 0.93 | EIF2AK4 (0.53) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16245663 | 0.89 | EIF2AK4 (0.54) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16245601 | 0.85 | EIF2AK4 (0.52) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16245707 | 0.84 | EIF2AK4 (0.47) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16245596 | 0.81 | EIF2AK4 (0.59) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16246003 | 0.80 | EIF2AK4 (0.52) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL17821176 | 0.80 | EIF2AK4 (0.55) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16264861 | 0.80 | EIF2AK4 (0.55) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL17821175 | 0.79 | EIF2AK4 (0.56) | EIF2AK4MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16245534 | 0.77 | GSK3A (0.57) | EIF2AK4MAPK6GSK3AGSK3BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861635-B2 | Macrocycles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | EIF2AK4, CDK2, CDK1 | EIF2AK4 1/4885MAPK6 179/4885GSK3A 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.