Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP2 | P42575 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2831078 | 1.00 | HRH3 (0.32) | HRH3MEN1MAPTMAPK1CASP2 | |
| Hydrochloric Acid SCHEMBL193045 | 0.98 | HRH3 (0.33) | HRH3MEN1MAPTMAPK1CASP2 | |
| SCHEMBL107551 | 0.96 | HRH3 (0.34) | HRH3 | |
| Fluoride Ion SCHEMBL5046809 | 0.94 | HRH3 (0.33) | HRH3 | |
| Bromide SCHEMBL193081 | 0.94 | HRH3 (0.33) | HRH3MEN1MAPTMAPK1KMT2A | |
| Iodide SCHEMBL247931 | 0.94 | HRH3 (0.33) | HRH3SMN1; SMN2 | |
| SCHEMBL8003081 | 0.94 | HRH3 (0.33) | HRH3 | |
| Water SCHEMBL1176980 | 0.94 | HRH3 (0.33) | HRH3 | |
| Hydrochloric Acid SCHEMBL2834153 | 0.92 | KCNH2 (0.36) | HRH3MEN1MAPTMAPK1CASP2 | |
| Bromide SCHEMBL15532008 | 0.92 | HRH3 (0.32) | HRH3MEN1MAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243745-B1 | Method for making a chlorosilane | VERSUM MAT US LLC (US) | 2019-06-19 | — | — | EP | disclosed |
| US-8206676-B2 | Method for making a chlorosilane | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20110113628-A1 | Method for Making a Chlorosilane | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| EP-2243745-A2 | Method for making a chlorosilane | Air Products and Chemicals, Inc. (US) | 2010-10-27 | — | — | EP | disclosed |