Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.55 |
| ▸ | MMP9 | P14780 | 7/20 | 0.55 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19665787 | 1.00 | MMP2 (0.55) | MMP2MMP9ADAMTS4ITGB3ITGA2B | |
| SCHEMBL19661136 | 0.81 | ITGB1 (0.66) | MMP2MMP9LMNAITGB1ITGA4 | |
| SCHEMBL17833024 | 0.81 | ITGB1 (0.66) | MMP2MMP9LMNAITGB1ITGA4 | |
| SCHEMBL6429531 | 0.81 | ITGB1 (0.66) | MMP2MMP9LMNAITGB1ITGA4 | |
| SCHEMBL19678647 | 0.81 | ITGB1 (0.66) | MMP2MMP9LMNAITGB1ITGA4 | |
| SCHEMBL23519701 | 0.81 | ITGB1 (0.66) | MMP2MMP9LMNAITGB1ITGA4 | |
| SCHEMBL19639190 | 0.81 | ITGB1 (0.66) | MMP2MMP9LMNAITGB1ITGA4 | |
| SCHEMBL19678622 | 0.81 | ITGB1 (0.66) | MMP2MMP9LMNAITGB1ITGA4 | |
| SCHEMBL21955605 | 0.80 | ITGB1 (0.65) | MMP2MMP9LMNAITGB1ITGA4 | |
| SCHEMBL23519442 | 0.79 | ITGB1 (0.47) | MEN1KMT2ALMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348375-A1 | DISLODGEMENT AND RELEASE OF HSC FROM THE BONE MARROW STEM CELL NICHE USING ALPHA9 INTEGRIN ANTAGONISTS | COMMW SCIENT IND RES ORG (AU) | 2017-12-07 | — | — | US | disclosed |
| CN-107405331-A | Migrated using the integrin antagonists of α 9 from stem cell tabernacle and discharge HSC | 联邦科学和工业研究组织 | 2017-11-28 | — | — | CN | disclosed |
| EP-3229797-A1 | DISLODGEMENT AND RELEASE OF HSC FROM THE BONE MARROW STEM CELL NICHE USING ALPHA9 INTEGRIN ANTAGONISTS | Commonwealth Scientific and Industrial Research Organisation (AU) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016090403-A1 | DISLODGEMENT AND RELEASE OF HSC FROM THE BONE MARROW STEM CELL NICHE USING ALPHA9 INTEGRIN ANTAGONISTS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348375-A1 | DISLODGEMENT AND RELEASE OF HSC FROM THE BONE MARROW STEM CELL NICHE USING ALPHA9 INTEGRIN ANTAGONISTS | CXCL12, BST2, CCR9 | MMP2 1492/4885MMP9 156/4885ADAMTS4 1858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.