SCHEMBL17823328

SCHEMBL17823328

O=[N+]([O-])c1cccc(OCOC(F)F)c1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.55
CHRNA4 P43681 2/20 0.55
LMNA P02545 2/20 0.48
TSHR P16473 1/20 0.48
CHRNB4 P30926 1/20 0.47
CHRNA3 P32297 1/20 0.47
GRM5 P41594 1/20 0.45
MAOB P27338 1/20 0.45
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
LTA4H P09960 1/20 0.43
PTGS2 P35354 1/20 0.43
MEN1 O00255 1/20 0.43
ALDH1A1 P00352 1/20 0.43
POLB P06746 1/20 0.43
KMT2A Q03164 1/20 0.43
HPGD P15428 1/20 0.43
F2 P00734 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16178929 0.87 CHRNB2 (0.64) CHRNB2CHRNA4LMNATSHRCHRNB4
SCHEMBL5149611 0.86 CHRNB2 (0.57) CHRNB2CHRNA4LMNATSHRCHRNB4
Hydrochloric Acid SCHEMBL10551173 0.85 CHRNB2 (0.62) CHRNB2CHRNA4LMNATSHRCHRNB4
Hydrochloric Acid SCHEMBL10551164 0.85 CHRNB2 (0.62) CHRNB2CHRNA4LMNATSHRCHRNB4
Hydrochloric Acid SCHEMBL10551171 0.85 CHRNB2 (0.62) CHRNB2CHRNA4LMNATSHRCHRNB4
SCHEMBL4701140 0.81 CHRNB2 (0.61) CHRNB2CHRNA4LMNATSHRCHRNB4
SCHEMBL6197458 0.80 TSHR (0.55) CHRNB2CHRNA4LMNATSHRMEN1
SCHEMBL1707857 0.80 CHRNB2 (0.60) CHRNB2CHRNA4LMNATSHRCHRNB4
SCHEMBL27600825 0.80 CHRNB2 (0.60) CHRNB2CHRNA4LMNATSHRCHRNB4
SCHEMBL15498199 0.80 CHRNB2 (0.73) CHRNB2CHRNA4LMNATSHRCHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3230274-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS Bayer Pharma Aktiengesellschaft (DE) 2017-10-18 EP disclosed
WO-2016091845-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-06-16 WO disclosed