Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.63 |
| ▸ | TTK | P33981 | 4/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.63 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | PRKDC | P78527 | 12/20 | 0.60 |
| ▸ | CSF1R | P07333 | 3/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.59 |
| ▸ | CDK4 | P11802 | 5/20 | 0.56 |
| ▸ | CCND1 | P24385 | 5/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.53 |
| ▸ | CCND2 | P30279 | 3/20 | 0.53 |
| ▸ | CCND3 | P30281 | 3/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781441 | 0.90 | TTK (0.73) | CDK2TTKCCNA2AURKAPRKDC | |
| SCHEMBL1782164 | 0.87 | TTK (0.70) | CDK2TTKCCNA2AURKAPRKDC | |
| SCHEMBL27196803 | 0.86 | CDK4 (0.60) | CDK2TTKCCNA2AURKACSF1R | |
| SCHEMBL29714305 | 0.86 | CDK4 (0.60) | CDK2TTKCCNA2AURKACSF1R | |
| SCHEMBL1781331 | 0.85 | CDK4 (0.71) | CDK2TTKCCNA2AURKAPRKDC | |
| SCHEMBL1780670 | 0.84 | TTK (0.62) | CDK2TTKCCNA2AURKAPRKDC | |
| SCHEMBL1780907 | 0.82 | TTK (0.63) | CDK2TTKCCNA2AURKAPRKDC | |
| SCHEMBL1781666 | 0.82 | TTK (0.60) | CDK2TTKCCNA2AURKAPRKDC | |
| SCHEMBL1782511 | 0.81 | TTK (0.67) | CDK2TTKCCNA2AURKAPRKDC | |
| SCHEMBL1781503 | 0.81 | CDK4 (0.65) | CDK2TTKCCNA2AURKACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-05-19 | — | — | US | disclosed |
| EP-2212326-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009024824-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BUB1, BUB1B, TTBK1 | CDK2 134/4885TTK 4/4885CCNA2 538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.