Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 7/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17834895 | 0.97 | S1PR1 (0.38) | S1PR1S1PR5S1PR3ITGB1ITGA5 | |
| SCHEMBL17834896 | 0.94 | S1PR1 (0.39) | S1PR1S1PR5S1PR3ITGB1ITGA5 | |
| SCHEMBL17834872 | 0.93 | S1PR1 (0.39) | S1PR1S1PR5S1PR3ITGB1ITGA5 | |
| SCHEMBL17834717 | 0.92 | S1PR5 (0.43) | S1PR1S1PR5S1PR3ITGB1ITGA5 | |
| SCHEMBL17834592 | 0.91 | S1PR5 (0.42) | S1PR1S1PR5S1PR3ITGB1ITGA5 | |
| SCHEMBL17834481 | 0.90 | S1PR5 (0.43) | S1PR1S1PR5S1PR3ITGB1ITGA5 | |
| SCHEMBL17834726 | 0.89 | S1PR1 (0.40) | S1PR1S1PR5S1PR3ITGB1ITGA5 | |
| SCHEMBL17825470 | 0.89 | S1PR1 (0.37) | S1PR1S1PR5S1PR3ITGB1ITGA4 | |
| SCHEMBL16305964 | 0.89 | S1PR1 (0.38) | S1PR1S1PR5S1PR3ITGB1ITGA5 | |
| SCHEMBL16295387 | 0.89 | S1PR1 (0.38) | S1PR1S1PR5S1PR3ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230276-A1 | GLP-1 RECEPTOR MODULATORS | Celgene International II Sarl (CH) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |