Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17834872 | 0.92 | S1PR1 (0.39) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL17834896 | 0.91 | S1PR1 (0.39) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL16305964 | 0.91 | S1PR1 (0.38) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL16295387 | 0.91 | S1PR1 (0.38) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL17995145 | 0.90 | ITGB1 (0.39) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL17834895 | 0.90 | S1PR1 (0.38) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL17825483 | 0.89 | S1PR1 (0.37) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL16305734 | 0.89 | RARB (0.38) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL17834871 | 0.88 | S1PR1 (0.43) | S1PR1S1PR5ITGB1ITGA5RARB | |
| SCHEMBL17834825 | 0.87 | S1PR1 (0.42) | S1PR1S1PR5RARBHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |