Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 2/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825619 | 1.00 | KMT2A (0.63) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL17825688 | 0.84 | KMT2A (0.58) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL17825638 | 0.84 | KMT2A (0.58) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL17825668 | 0.79 | KMT2A (0.54) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL17825666 | 0.79 | KMT2A (0.54) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL28260621 | 0.78 | KMT2A (0.63) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL28260620 | 0.78 | KMT2A (0.63) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL1498095 | 0.76 | TSHR (0.61) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL1498097 | 0.76 | TSHR (0.61) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL22632406 | 0.74 | KMT2A (0.67) | KMT2ACASP1SMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3229801-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2020-04-01 | — | — | EP | disclosed |
| US-10189819-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME, CORP. (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180030036-A1 | Factor IXa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-02-01 | — | — | US | disclosed |
| EP-3229801-A1 | FACTOR IXA INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094260-A1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030036-A1 | Factor IXa Inhibitors | F9, TFPI, F12 | KMT2A 4286/4885CASP1 727/4885SMN1; SMN2 3148/4885 |
| US-10189819-B2 | Factor IXa inhibitors | F9, TFPI, F12 | KMT2A 4286/4885CASP1 727/4885SMN1; SMN2 3148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.