Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 0.67 |
| ▸ | CCND1 | P24385 | 13/20 | 0.67 |
| ▸ | CCND2 | P30279 | 9/20 | 0.67 |
| ▸ | CCND3 | P30281 | 9/20 | 0.67 |
| ▸ | CDK2 | P24941 | 7/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.67 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.67 |
| ▸ | CDK1 | P06493 | 4/20 | 0.67 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.67 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.67 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.63 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.63 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.63 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.62 |
| ▸ | PRKDC | P78527 | 4/20 | 0.62 |
| ▸ | PAK4 | O96013 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781331 | 0.93 | CDK4 (0.71) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL1781620 | 0.92 | CDK4 (0.68) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL1781852 | 0.91 | CDK4 (0.62) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL1781854 | 0.90 | PRKDC (0.59) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL1782006 | 0.83 | PRKDC (0.60) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL3967349 | 0.82 | CDK4 (0.80) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL1781846 | 0.82 | PRKDC (0.62) | CDK2CCNA2CCNE2CCNE1CDK1 | |
| SCHEMBL1780821 | 0.81 | PRKDC (0.63) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL1781065 | 0.81 | PRKDC (0.68) | CDK2CCNA2PRKDCCSF1RTTK | |
| SCHEMBL1782804 | 0.81 | PRKDC (0.69) | CDK4CCND1CCND2CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-05-19 | — | — | US | disclosed |
| EP-2212326-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009024824-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BUB1, BUB1B, TTBK1 | CDK4 648/4885CCND1 612/4885CCND2 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.