Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16420565 | 0.89 | ATR (0.71) | ATR | |
| SCHEMBL17826182 | 0.86 | NPC1 (0.44) | ATR | |
| SCHEMBL17826129 | 0.86 | RAB9A (0.46) | ATR | |
| SCHEMBL17826139 | 0.85 | ATR (0.45) | ATR | |
| SCHEMBL17826180 | 0.85 | ATR (0.41) | ATR | |
| SCHEMBL17826111 | 0.85 | NPC1 (0.48) | ATR | |
| SCHEMBL17826206 | 0.85 | ATR (0.49) | ATR | |
| SCHEMBL17826108 | 0.84 | ATR (0.46) | ATR | |
| SCHEMBL17826191 | 0.84 | ATR (0.45) | ATR | |
| SCHEMBL17826135 | 0.84 | ATR (0.40) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365557-B2 | Substituted pyrazin-2-amines as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-06-14 | — | — | US | disclosed |