Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 13/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15793556 | 0.91 | TDP1 (0.59) | ELANECYP2C9CYP2C8CYP2C19LMNA | |
| SCHEMBL15793557 | 0.91 | TDP1 (0.59) | ELANECYP2C9CYP2C8CYP2C19LMNA | |
| SCHEMBL15793286 | 0.83 | TDP1 (0.56) | ELANECYP2C9CYP2C8CYP2C19LMNA | |
| SCHEMBL15793288 | 0.83 | TDP1 (0.56) | ELANECYP2C9CYP2C8CYP2C19LMNA | |
| SCHEMBL7939908 | 0.81 | ELANE (0.63) | ELANECYP2C9CYP2C8CYP2C19LMNA | |
| SCHEMBL10013432 | 0.80 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19LMNA | |
| SCHEMBL7906666 | 0.80 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19LMNA | |
| SCHEMBL17477254 | 0.79 | ELANE (0.66) | ELANECYP2C9CYP2C8CYP2C19 | |
| SCHEMBL8055913 | 0.79 | ELANE (0.65) | ELANECYP2C9CYP2C8CYP2C19LMNA | |
| SCHEMBL7901491 | 0.79 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365577-B2 | Pyrimidinone compounds as human neutrophil elastase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-06-14 | — | — | US | disclosed |
| US-9365577-B2 | Pyrimidinone compounds as human neutrophil elastase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-06-14 | — | — | US | disclosed |