Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.46 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781083 | 0.88 | PIK3CD (0.48) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| SCHEMBL1781032 | 0.87 | PIK3CD (0.47) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| SCHEMBL1781030 | 0.87 | PIK3CD (0.47) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| SCHEMBL1779532 | 0.87 | PIK3CD (0.47) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| Formic Acid SCHEMBL1778882 | 0.85 | PIK3CD (0.46) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| SCHEMBL1780856 | 0.85 | PIK3CD (0.53) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| SCHEMBL1780999 | 0.84 | PIK3CD (0.46) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| SCHEMBL1771412 | 0.83 | PIK3CD (0.53) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| SCHEMBL1780481 | 0.83 | PIK3CD (0.43) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 | |
| SCHEMBL1771818 | 0.82 | PIK3CD (0.52) | PIK3CAPIK3CDPIK3CGPIK3CBPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765743-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-01 | — | — | US | claimed |
| US-20110118246-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-05-19 | — | — | US | claimed |
| US-9326987-B2 | Indazole derivatives for use in the treatment of influenza virus infection | GLAXO GROUP LIMITED (GB) | 2016-05-03 | — | — | US | disclosed |
| US-8765743-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-01 | — | — | US | disclosed |
| US-8765743-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-01 | — | — | US | disclosed |
| US-20130165433-A1 | Novel Use | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-06-27 | — | — | US | disclosed |
| US-20110118246-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-05-19 | — | — | US | disclosed |
| US-20110118246-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165433-A1 | Novel Use | HAVCR2, MAVS, ENTPD5 | PIK3CA 2691/4885PIK3CD 2938/4885PIK3CG 2718/4885 |
| US-20110118246-A1 | Novel Compounds | PIK3CA, PIK3C2B, PIK3CD | PIK3CA 1/4885PIK3CD 3/4885PIK3CG 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.