Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | BCHE | P06276 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Avanbulin SCHEMBL29374555 | 0.91 | KDM4E (0.56) | ALDH1A1KDM4EHSD17B10BCHESMN1; SMN2 | |
| Avanbulin SCHEMBL1160317 | 0.91 | KDM4E (0.56) | ALDH1A1KDM4EHSD17B10BCHESMN1; SMN2 | |
| Avanbulin SCHEMBL9099635 | 0.90 | KDM4E (0.55) | ALDH1A1KDM4EHSD17B10BCHESMN1; SMN2 | |
| SCHEMBL23118938 | 0.87 | KDM4E (0.53) | ALDH1A1KDM4EHSD17B10BCHESMN1; SMN2 | |
| SCHEMBL11891125 | 0.87 | KDM4E (0.55) | KDM4EBCHESMN1; SMN2TP53MAPT | |
| SCHEMBL18714136 | 0.86 | KDM4E (0.52) | ALDH1A1KDM4EHSD17B10BCHESMN1; SMN2 | |
| SCHEMBL2584579 | 0.85 | KDM4E (0.58) | ALDH1A1KDM4EBCHESMN1; SMN2TP53 | |
| SCHEMBL18791198 | 0.85 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10BCHESMN1; SMN2 | |
| SCHEMBL11890502 | 0.84 | KDM4E (0.73) | KDM4EBCHESMN1; SMN2TP53MAPT | |
| SCHEMBL11301075 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10BCHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9366682-B2 | Use of stathmin as a biomarker of drug response to furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2016-06-14 | — | — | US | disclosed |
| US-9366682-B2 | Use of stathmin as a biomarker of drug response to furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2016-06-14 | — | — | US | disclosed |