Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.41 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31555358 | 0.83 | CYP1A2 (0.52) | MAP4K4SREBF1SREBF2CYP3A4CYP1A2 | |
| SCHEMBL13273291 | 0.82 | SREBF2 (0.50) | MAP4K4SREBF1SREBF2CYP3A4KDM4E | |
| SCHEMBL8257156 | 0.82 | SREBF2 (0.48) | MAP4K4SREBF1SREBF2CYP3A4CYP1A2 | |
| SCHEMBL10272612 | 0.81 | SREBF1 (0.49) | MAP4K4SREBF1SREBF2CYP1A2KMO | |
| SCHEMBL10272990 | 0.80 | FGFR1 (0.42) | MAP4K4SREBF1SREBF2CYP3A4KDM4E | |
| SCHEMBL11176714 | 0.79 | MAP4K4 (0.49) | MAP4K4SREBF1SREBF2CYP3A4CYP1A2 | |
| SCHEMBL11372896 | 0.79 | SREBF2 (0.54) | SREBF2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1507045 | 0.79 | — | — | |
| SCHEMBL28021728 | 0.79 | PDE4B (0.53) | MAP4K4PDE4BDHFRCYP3A4KDM4E | |
| SCHEMBL13273052 | 0.78 | CNR2 (0.47) | CNR2MAP4K4PDE4BTAAR1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379535-B1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2016-06-15 | — | — | EP | disclosed |