Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256379 | 0.79 | PARP1 (0.50) | DYRK1APARP1MTNR1AL3MBTL1KDM4E | |
| SCHEMBL29845529 | 0.79 | PARP1 (0.50) | DYRK1APARP1MTNR1AL3MBTL1KDM4E | |
| Bromide SCHEMBL28427695 | 0.78 | PARP1 (0.49) | DYRK1APARP1MTNR1AL3MBTL1KDM4E | |
| SCHEMBL29468208 | 0.71 | AHR (0.47) | DYRK1AMTNR1AKDM4ECYP3A4CYP2D6 | |
| SCHEMBL29865575 | 0.67 | PARP1 (0.55) | PARP1MTNR1AL3MBTL1KDM4ECYP3A4 | |
| SCHEMBL28822882 | 0.67 | PARP1 (0.55) | PARP1MTNR1AL3MBTL1KDM4ECYP3A4 | |
| SCHEMBL29712289 | 0.67 | BRD4 (0.50) | PARP1MTNR1AL3MBTL1KDM4ECYP3A4 | |
| SCHEMBL2614748 | 0.67 | BRD4 (0.50) | PARP1MTNR1AL3MBTL1KDM4ECYP3A4 | |
| SCHEMBL17818443 | 0.66 | CYP2C19 (0.73) | L3MBTL1LMNAMAPTTSHRHTT | |
| SCHEMBL5437233 | 0.66 | AXL (0.64) | DYRK1APARP1MTNR1AL3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168147-A1 | ISOTOPICALLY ENRICHED AZAINDOLES | VERTEX PHARMA (US) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168147-A1 | ISOTOPICALLY ENRICHED AZAINDOLES | JAK2, JAK1, JAK3 | DYRK1A 373/4885PARP1 1336/4885MTNR1A 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.