Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 17/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.52 |
| ▸ | PRKCI | P41743 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829985 | 0.96 | TLR8 (0.51) | TLR8TLR7PRKCI | |
| SCHEMBL7683034 | 0.83 | PRKCI (0.46) | TLR8TLR7PRKCI | |
| SCHEMBL7687751 | 0.80 | PRKCI (0.45) | TLR8TLR7PRKCI | |
| SCHEMBL22448319 | 0.79 | TLR8 (0.42) | TLR8TLR7PRKCI | |
| SCHEMBL7677137 | 0.78 | PRKCI (0.44) | TLR8PRKCI | |
| SCHEMBL7680936 | 0.78 | PRKCI (0.44) | TLR8PRKCI | |
| SCHEMBL7677206 | 0.78 | PRKCI (0.44) | TLR8PRKCI | |
| SCHEMBL7688013 | 0.78 | SLC29A1 (0.43) | TLR8TLR7PRKCI | |
| SCHEMBL22448322 | 0.76 | PRKCI (0.43) | TLR8TLR7PRKCI | |
| SCHEMBL22448327 | 0.76 | TLR8 (0.54) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822347-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | Janssen Sciences Ireland Unlimited Company (IE) | 2020-11-03 | — | — | US | disclosed |
| EP-3404031-B1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2020-09-23 | — | — | EP | disclosed |
| US-20190330227-A1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2019-10-31 | — | — | US | disclosed |
| US-10316043-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | Janssen Sciences Ireland Unlimited Company (IE) | 2019-06-11 | — | — | US | disclosed |
| US-20170298079-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-10-19 | — | — | US | disclosed |
| US-20170298079-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-10-19 | — | — | US | disclosed |
| US-9556199-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | JANSSEN SCIENCES IRELAND UC (IE) | 2017-01-31 | — | — | US | disclosed |
| US-9556199-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | JANSSEN SCIENCES IRELAND UC (IE) | 2017-01-31 | — | — | US | disclosed |
| US-20160168164-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-06-16 | — | — | US | disclosed |
| US-20160168164-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168164-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | TYMS, TYMP, UMPS | TLR8 1457/4885TLR7 766/4885PRKCI 3542/4885 |
| US-20190330227-A1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | TYMS, TYMP, UMPS | TLR8 1457/4885TLR7 766/4885PRKCI 3542/4885 |
| US-20170298079-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | TYMS, TYMP, UMPS | TLR8 1457/4885TLR7 766/4885PRKCI 3542/4885 |
| US-10316043-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | TYMS, TYMP, UMPS | TLR8 1457/4885TLR7 766/4885PRKCI 3542/4885 |
| US-10822347-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | TYMS, TYMP, UMPS | TLR8 1457/4885TLR7 766/4885PRKCI 3542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.