SCHEMBL17830731

SCHEMBL17830731

COC(=O)Cn1c(=O)oc2cc(Cl)ccc21

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.61
TP53 P04637 2/20 0.61
MAPT P10636 2/20 0.61
ALDH1A1 P00352 3/20 0.56
USP2 O75604 1/20 0.56
KMT2A Q03164 4/20 0.55
MEN1 O00255 3/20 0.55
HSD17B10 Q99714 3/20 0.54
HPGD P15428 2/20 0.54
CYP3A4 P08684 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
PIK3CB P42338 1/20 0.54
POLB P06746 3/20 0.53
IDO1 P14902 2/20 0.52
GAA P10253 1/20 0.51
MAPK1 P28482 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17830716 0.87 LMNA (0.53) LMNATP53MAPTALDH1A1USP2
SCHEMBL14564389 0.85 MIF (0.56) TP53MAPTALDH1A1KMT2AMEN1
SCHEMBL5640765 0.84 TP53 (0.47) LMNATP53MAPTALDH1A1USP2
SCHEMBL4411764 0.84 TP53 (0.61) LMNATP53MAPTALDH1A1KMT2A
SCHEMBL13140318 0.84 TP53 (0.58) LMNATP53MAPTALDH1A1KMT2A
SCHEMBL14876430 0.84 TP53 (0.47) LMNATP53MAPTALDH1A1USP2
SCHEMBL2978251 0.83 PIK3CB (0.58) LMNATP53MAPTKMT2AMEN1
SCHEMBL5665732 0.82 TP53 (0.57) LMNATP53MAPTALDH1A1USP2
SCHEMBL17830724 0.82 IDO1 (0.51) LMNATP53MAPTALDH1A1USP2
SCHEMBL4414360 0.82 HPGD (0.64) LMNATP53MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9943506-B2 BCL6 inhibitors as anticancer agents CORNELL UNIVERSITY (US) 2018-04-17 US disclosed
US-9943506-B2 BCL6 inhibitors as anticancer agents CORNELL UNIVERSITY (US) 2018-04-17 US disclosed
US-20160166549-A1 BCL6 INHIBITORS AS ANTICANCER AGENTS CORNELL UNIVERSITY 2016-06-16 US disclosed
US-20160166549-A1 BCL6 INHIBITORS AS ANTICANCER AGENTS CORNELL UNIVERSITY 2016-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160166549-A1 BCL6 INHIBITORS AS ANTICANCER AGENTS BCL6, BCL6B, BAZ2A LMNA 3890/4885TP53 158/4885MAPT 2263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.