Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12310045 | 0.86 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1HSD17B10POLB | |
| SCHEMBL13831426 | 0.73 | MAPT (0.60) | ALDH1A1KMT2AMEN1POLBHPGD | |
| SCHEMBL6410649 | 0.70 | ALPG (0.66) | ALDH1A1KMT2AMEN1HSD17B10POLB | |
| SCHEMBL13096451 | 0.69 | MAPT (0.66) | ALDH1A1KMT2AMEN1HSD17B10POLB | |
| SCHEMBL13831868 | 0.67 | POLB (0.64) | ALDH1A1KMT2AMEN1POLBHPGD | |
| SCHEMBL16896272 | 0.67 | POLB (0.45) | ALDH1A1KMT2AMEN1HSD17B10POLB | |
| SCHEMBL15986452 | 0.67 | ANXA2 (0.54) | ALDH1A1KMT2AMEN1POLBHPGD | |
| SCHEMBL20159334 | 0.67 | HPGD (0.58) | ALDH1A1KMT2AMEN1HSD17B10POLB | |
| SCHEMBL30619609 | 0.65 | HPGD (0.52) | ALDH1A1KMT2AMEN1HSD17B10POLB | |
| SCHEMBL28648414 | 0.65 | HPGD (0.52) | ALDH1A1KMT2AMEN1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160171150-A1 | Chemical Modulators of Pro-Apoptotic BAX and BCL-2 Polypeptides | DANA-FARBER CANCER INSTITUTE, INC. | 2016-06-16 | — | — | US | disclosed |