Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28175732 | 0.86 | PIK3CA (0.53) | PIK3CASLC22A12ALDH1A1MAPTNPSR1 | |
| SCHEMBL28140817 | 0.84 | ALK (0.49) | PIK3CASLC22A12NCF1ALDH1A1MAPT | |
| SCHEMBL30440259 | 0.83 | PIK3CA (0.62) | PIK3CASLC22A12AURKAKDRAURKB | |
| SCHEMBL12277881 | 0.83 | PIK3CA (0.62) | PIK3CASLC22A12AURKAKDRAURKB | |
| SCHEMBL731933 | 0.83 | PIK3CA (0.62) | PIK3CASLC22A12NCF1HTTSMN1; SMN2 | |
| SCHEMBL21964214 | 0.78 | PIK3CA (0.43) | PIK3CASLC22A12NCF1MAPTHTT | |
| SCHEMBL17833790 | 0.78 | PIK3CA (0.46) | PIK3CASLC22A12MAPK1ALDH1A1MAPT | |
| SCHEMBL17060466 | 0.78 | MAPT (0.53) | SLC22A12AURKAAURKBMAPK1ALDH1A1 | |
| SCHEMBL28295739 | 0.77 | PIK3CA (0.48) | PIK3CAALDH1A1MAPTNPSR1CCNB2 | |
| SCHEMBL3849357 | 0.77 | RPS6KA3 (0.44) | PIK3CASLC22A12HTTGAKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168118-A1 | N-(5-QUINOLIN-6-YL)PYRIDIN-3-YL) BENZSULFAMIDE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE THEREOF | SECOND MILITARY MEDICAL UNIVERSITY, PLA (CN) | 2016-06-16 | — | — | US | disclosed |
| US-20160168118-A1 | N-(5-QUINOLIN-6-YL)PYRIDIN-3-YL) BENZSULFAMIDE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE THEREOF | SECOND MILITARY MEDICAL UNIVERSITY, PLA (CN) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168118-A1 | N-(5-QUINOLIN-6-YL)PYRIDIN-3-YL) BENZSULFAMIDE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE THEREOF | GLS2, CYP3A5, HCCS | PIK3CA 532/4885SLC22A12 3126/4885AURKA 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.