SCHEMBL17834719

SCHEMBL17834719

Nc1nc2c([C@H]3C[C@@H](O)[C@@H](CO)O3)c[nH]c2c(=O)[nH]1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PNP P00491 8/20 0.62
HPRT1 P00492 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12729546 1.00 PNP (0.62) PNPHPRT1
SCHEMBL19242687 0.81 PNP (0.60) PNP
SCHEMBL12729511 0.80 HPRT1 (0.51) PNPHPRT1
SCHEMBL17833851 0.80 HPRT1 (0.51) PNPHPRT1
SCHEMBL3302990 0.80 PNP (0.81) PNPHPRT1
SCHEMBL3302997 0.80 PNP (0.81) PNPHPRT1
SCHEMBL13074882 0.79 DNMT1 (0.42) PNP
SCHEMBL24420510 0.76 ADRB1 (0.42) PNP
SCHEMBL27054425 0.76 ADRB1 (0.42) PNP
SCHEMBL3365040 0.76 PNP (0.54) PNPHPRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160168636-A1 NUCLEOTIDE ANALOGS HELICOS BIOSCIENCES CORPORATION 2016-06-16 US disclosed