Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22167263 | 0.95 | S1PR4 (0.38) | S1PR1S1PR5S1PR4S1PR3PRCP | |
| SCHEMBL19485602 | 0.95 | PRCP (0.38) | S1PR1S1PR5S1PR4S1PR3PRCP | |
| SCHEMBL17834841 | 0.94 | S1PR1 (0.35) | S1PR1S1PR5S1PR4S1PR3PRCP | |
| SCHEMBL17834650 | 0.94 | S1PR1 (0.35) | S1PR1S1PR5S1PR4S1PR3PRCP | |
| SCHEMBL17834844 | 0.94 | S1PR1 (0.35) | S1PR1S1PR5S1PR4S1PR3PRCP | |
| SCHEMBL17995219 | 0.94 | S1PR1 (0.34) | S1PR1S1PR5S1PR4S1PR3PRCP | |
| SCHEMBL17834484 | 0.94 | MAPK1 (0.37) | S1PR1S1PR5S1PR4S1PR3PYGL | |
| SCHEMBL17834744 | 0.94 | S1PR1 (0.33) | S1PR1S1PR5S1PR4S1PR3PRCP | |
| SCHEMBL17834485 | 0.94 | S1PR1 (0.34) | S1PR1S1PR5S1PR4S1PR3PRCP | |
| SCHEMBL19485634 | 0.94 | S1PR1 (0.34) | S1PR1S1PR5S1PR4S1PR3PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10034886-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2018-07-31 | — | — | US | disclosed |
| US-20180021346-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS LLC | 2018-01-25 | — | — | US | disclosed |
| US-9795613-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2017-10-24 | — | — | US | disclosed |
| US-20160228450-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS LLC | 2016-08-11 | — | — | US | disclosed |
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160228450-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, NPY1R | S1PR1 486/4885S1PR5 889/4885S1PR4 665/4885 |
| US-20180021346-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, NPY1R | S1PR1 486/4885S1PR5 889/4885S1PR4 665/4885 |
| US-10034886-B2 | GLP-1 receptor modulators | GLP1R, GIPR, GCGR | S1PR1 523/4885S1PR5 939/4885S1PR4 713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.