Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773871 | 0.83 | APP (0.47) | TSHRNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9269290 | 0.82 | NR5A1 (0.50) | TSHRLTA4HNPC1MAPTLMNA | |
| SCHEMBL1775357 | 0.78 | APP (0.39) | TSHRTDP1 | |
| SCHEMBL7423260 | 0.77 | NPC1 (0.39) | NPC1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10053321 | 0.77 | MAOA (0.37) | — | |
| SCHEMBL18883698 | 0.77 | NQO1 (0.64) | NQO1TSHRTDP1LTA4HNPC1 | |
| SCHEMBL10346021 | 0.77 | NQO1 (0.64) | NQO1TSHRTDP1LTA4HNPC1 | |
| SCHEMBL945559 | 0.76 | NQO1 (0.70) | NQO1TSHRTDP1LTA4HNPC1 | |
| SCHEMBL1775568 | 0.76 | NPC1 (0.37) | TSHRTDP1NPC1KMT2AALDH1A1 | |
| SCHEMBL9273164 | 0.76 | BACE1 (0.40) | TSHRTDP1LTA4HMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034075-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Holdings Corporation (US) | 2016-06-22 | — | — | EP | disclosed |