Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | CCR8 | P51685 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1160994 | 0.80 | KDM4E (0.48) | NR4A2KDM4EMAPTL3MBTL1MPI | |
| SCHEMBL29870703 | 0.80 | KDM4E (0.48) | NR4A2KDM4EMAPTL3MBTL1MPI | |
| SCHEMBL29702168 | 0.80 | NR4A2 (0.67) | NR4A2KDM4EMAPTL3MBTL1SOS2 | |
| SCHEMBL7712335 | 0.80 | NR4A2 (0.67) | NR4A2KDM4EMAPTL3MBTL1SOS2 | |
| SCHEMBL15765873 | 0.77 | NR4A2 (0.62) | NR4A2KDM4EMAPTL3MBTL1SOS2 | |
| SCHEMBL31606740 | 0.77 | NR4A2 (0.62) | NR4A2KDM4EMAPTL3MBTL1SOS2 | |
| SCHEMBL18572648 | 0.77 | NR4A2 (0.62) | NR4A2KDM4EMAPTL3MBTL1MPI | |
| SCHEMBL2171872 | 0.77 | NR4A2 (0.62) | NR4A2KDM4EMAPTL3MBTL1SOS2 | |
| SCHEMBL29937108 | 0.77 | ALDH1A1 (0.48) | NR4A2KDM4EMAPTL3MBTL1MPI | |
| SCHEMBL115816 | 0.77 | NR4A2 (0.49) | NR4A2KDM4EMAPTL3MBTL1MPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237401-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | Pfizer Inc (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9738626-B2 | Antagonists of prostaglandin EP3 receptor | PFIZER INC. (US) | 2017-08-22 | — | — | US | disclosed |
| WO-2016103097-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PFIZER INC. (US) | 2016-06-30 | — | — | WO | disclosed |
| US-20160176851-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PFIZER INC. (US) | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176851-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PTGER3, PTGES3, PTGER2 | NR4A2 560/4885KDM4E 3987/4885MAPT 4882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.