Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.71 |
| ▸ | F3 | P13726 | 1/20 | 0.71 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.71 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.71 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.71 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.71 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.71 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.71 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | APP | P05067 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.62 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalamic Acid SCHEMBL7674497 | 0.92 | F7 (0.79) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL28589259 | 0.90 | F7 (0.81) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL29596610 | 0.90 | F7 (0.81) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL1462628 | 0.88 | F7 (0.85) | F7F3SARM1SIRT2SIRT6 | |
| Aminobenzoic Acid SCHEMBL9443950 | 0.87 | F7 (0.71) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL18938563 | 0.87 | F7 (0.76) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL675207 | 0.86 | F7 (0.96) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL460466 | 0.84 | F7 (1.00) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL2926 | 0.84 | — | — | |
| Niacinamide SCHEMBL29624874 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237422-A1 | CO-CRYSTALS OF 5-AMINO-2-OXOTHIAZOLO[4,5-D]PYRIMIDIN-3(2H)-YL-5-HYDROXYMETHYL TETRAHYDROFURAN-3-YL ACETATE AND METHODS FOR PREPARING AND USING THE SAME | F. Hoffmann-La Roche AG (CH) | 2017-11-01 | — | — | EP | disclosed |
| US-9676793-B2 | Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same | HOFFMANN-LAROCHE INC. (US) | 2017-06-13 | — | — | US | disclosed |
| WO-2016103166-A1 | CO-CRYSTALS OF 5-AMINO-2-OXOTHIAZOLO[4,5-D]PYRIMIDIN-3(2H)-YL-5-HYDROXYMETHYL TETRAHYDROFURAN-3-YL ACETATE AND METHODS FOR PREPARING AND USING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-30 | — | — | WO | disclosed |
| US-20160176899-A1 | CO-CRYSTALS OF 5-AMINO-2-OXOTHIAZOLO[4,5-D]PYRIMIDIN-3(2H)-YL-5-HYDROXYMETHYL TETRAHYDROFURAN-3-YL ACETATE AND METHODS FOR PREPARING AND USING THE SAME | HOFFMANN-LA ROCHE INC. | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176899-A1 | CO-CRYSTALS OF 5-AMINO-2-OXOTHIAZOLO[4,5-D]PYRIMIDIN-3(2H)-YL-5-HYDROXYMETHYL TETRAHYDROFURAN-3-YL ACETATE AND METHODS FOR PREPARING AND USING THE SAME | SLC10A1, HCCS, HAVCR2 | F7 1854/4885F3 2465/4885SARM1 3550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.