Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 13/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CPS1 | P31327 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17837908 | 0.86 | GPR119 (0.53) | — | |
| SCHEMBL5776479 | 0.81 | PDE4B (0.35) | GPR6 | |
| SCHEMBL4689209 | 0.75 | GPR6 (0.40) | GPR6MGLL | |
| SCHEMBL5774974 | 0.74 | EGFR (0.44) | EGFR | |
| SCHEMBL1142588 | 0.73 | GPR119 (0.53) | — | |
| SCHEMBL26123273 | 0.73 | DRD4 (0.40) | MGLL | |
| SCHEMBL26123279 | 0.73 | DRD4 (0.40) | MGLL | |
| SCHEMBL26126288 | 0.73 | DRD4 (0.40) | MGLL | |
| SCHEMBL15375545 | 0.73 | PDE4B (0.48) | GPR6 | |
| SCHEMBL31336127 | 0.72 | EPHX2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233829-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | Pfizer Inc (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |