Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | MTOR | P42345 | 4/20 | 0.33 |
| ▸ | GPR183 | P32249 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844729 | 1.00 | PAK4 (0.61) | PAK4NAMPTPAK1GABRA5STAT3 | |
| SCHEMBL19753620 | 0.91 | PAK4 (0.63) | PAK4NAMPTPAK1GABRA5PIK3CA | |
| SCHEMBL17859237 | 0.86 | PAK4 (0.59) | PAK4NAMPTPAK1GABRA5STAT3 | |
| SCHEMBL17844711 | 0.85 | PAK4 (0.62) | PAK4NAMPTPAK1GABRA5STAT3 | |
| SCHEMBL17844712 | 0.85 | PAK4 (0.62) | PAK4NAMPTPAK1GABRA5STAT3 | |
| SCHEMBL17844697 | 0.85 | GABRA5 (0.42) | PAK4GABRA5STAT3HPGDHRH3 | |
| SCHEMBL17859535 | 0.85 | PAK4 (0.63) | PAK4NAMPTPAK1GABRA5STAT3 | |
| SCHEMBL16347385 | 0.85 | PAK4 (0.79) | PAK4NAMPTPAK1GABRA5STAT3 | |
| SCHEMBL29611634 | 0.85 | PAK4 (0.79) | PAK4NAMPTPAK1GABRA5STAT3 | |
| SCHEMBL18317339 | 0.85 | PAK4 (0.79) | PAK4NAMPTPAK1GABRA5STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100515-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2016-06-23 | — | — | WO | disclosed |