Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21271453 | 0.88 | POLB (0.49) | AAK1KMT2A | |
| SCHEMBL20139043 | 0.88 | POLB (0.49) | AAK1KMT2A | |
| SCHEMBL20907724 | 0.87 | AAK1 (0.41) | AAK1ALDH1A1MAPK1LMNA | |
| SCHEMBL5662378 | 0.87 | AAK1 (0.41) | AAK1ALDH1A1MAPK1LMNA | |
| SCHEMBL20154372 | 0.84 | AAK1 (0.43) | AAK1KMT2ATAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL20154293 | 0.84 | AAK1 (0.43) | AAK1KMT2ATAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL20154292 | 0.84 | AAK1 (0.43) | AAK1KMT2ATAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL20908105 | 0.84 | MAPK1 (0.42) | AAK1ALDH1A1GAAMAPK1KDM4E | |
| SCHEMBL29640301 | 0.84 | MAPK1 (0.42) | AAK1ALDH1A1GAAMAPK1KDM4E | |
| SCHEMBL17844850 | 0.83 | AAK1 (0.42) | AAK1KMT2ATAS1R3TAS1R1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095088-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |