Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27983615 | 1.00 | MAPT (0.43) | MAPTKMT2AEGFRLMNAMEN1 | |
| SCHEMBL27666225 | 0.79 | HCAR2 (0.50) | MAPTKMT2AEGFRLMNAMEN1 | |
| SCHEMBL17465167 | 0.79 | HCAR2 (0.50) | MAPTKMT2AEGFRLMNAMEN1 | |
| SCHEMBL20482479 | 0.78 | KMT2A (0.48) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL28862367 | 0.78 | MAPT (0.47) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL28305489 | 0.78 | MAPT (0.45) | MAPTKMT2AEGFRLMNAMEN1 | |
| SCHEMBL27726323 | 0.77 | MAPT (0.46) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL27726319 | 0.77 | MAPT (0.46) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL29112408 | 0.77 | MAPT (0.46) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL11118451 | 0.76 | ALDH1A1 (0.51) | KMT2ALMNAHCAR2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095088-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |