Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848069 | 0.79 | MAPK1 (0.41) | MAPK1ALDH1A1NPSR1 | |
| SCHEMBL17846030 | 0.78 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL17844744 | 0.78 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL21535625 | 0.76 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL17848004 | 0.76 | MAPK1 (0.39) | MAPK1ALDH1A1MAPTRAB9A | |
| SCHEMBL17848017 | 0.76 | MAPK1 (0.36) | MAPK1 | |
| SCHEMBL17846050 | 0.75 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL17848036 | 0.73 | MAPK1 (0.39) | MAPK1 | |
| SCHEMBL17846289 | 0.71 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL17846189 | 0.70 | MAPK1 (0.43) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095088-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |