Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848005 | 0.78 | NOS1 (0.35) | MAPK1NOS1 | |
| SCHEMBL17848043 | 0.78 | NOS1 (0.31) | NOS1 | |
| SCHEMBL17846441 | 0.76 | MAPK1 (0.41) | MAPK1NOS1 | |
| SCHEMBL17846433 | 0.72 | NAMPT (0.35) | NOS1 | |
| SCHEMBL17844819 | 0.71 | MAPK1 (0.33) | MAPK1 | |
| SCHEMBL22661958 | 0.69 | NOS1 (0.38) | NOS1 | |
| SCHEMBL28552195 | 0.69 | ALDH1A1 (0.34) | MEN1KMT2A | |
| SCHEMBL17846105 | 0.69 | NOS1 (0.30) | NOS1 | |
| SCHEMBL17847946 | 0.67 | NOS1 (0.41) | NOS1 | |
| SCHEMBL30966926 | 0.66 | NOS1 (0.44) | NOS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095089-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |