Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17845255 | 0.88 | PRKCI (0.49) | PRKCICYP3A4NAMPTXDHKDM4E | |
| Potassium Ion SCHEMBL2918768 | 0.79 | PRKCI (0.42) | PRKCICYP3A4NAMPTXDHKDM4E | |
| SCHEMBL27786197 | 0.79 | PRKCI (0.42) | PRKCICYP3A4NAMPTXDHKDM4E | |
| SCHEMBL1266021 | 0.79 | MMP12 (0.42) | PRKCICYP3A4NAMPTXDHKDM4E | |
| SCHEMBL4429284 | 0.79 | PRKCI (0.42) | PRKCICYP3A4NAMPTXDHKDM4E | |
| SCHEMBL571363 | 0.79 | PRKCI (0.42) | PRKCICYP3A4NAMPTXDHKDM4E | |
| SCHEMBL362000 | 0.79 | POLB (0.50) | PRKCICYP3A4NAMPTXDHKDM4E | |
| SCHEMBL28975737 | 0.78 | HDAC6 (0.41) | PRKCICYP3A4NAMPTXDHKDM4E | |
| SCHEMBL2918763 | 0.78 | HDAC6 (0.41) | PRKCICYP3A4NAMPTXDHKDM4E | |
| SCHEMBL11783635 | 0.77 | JAK2 (0.41) | PRKCICYP3A4NAMPTXDHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233845-A1 | PARG INHIBITORY COMPOUNDS | Cancer Research Technology Limited (GB) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097749-A1 | PARG INHIBITORY COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-23 | — | — | WO | disclosed |