SCHEMBL17845450

SCHEMBL17845450

NS(=O)(=O)c1cc2c(cc1F)n(CC1(CF)CC1)c(=O)n2-c1nnc(C(F)F)s1

nearest known ligand 0.62

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PARG Q86W56 20/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17845616 0.88 PARG (0.65) PARG
SCHEMBL17845421 0.81 PARG (0.57) PARG
SCHEMBL17845675 0.79 PARG (0.56) PARG
SCHEMBL17845353 0.78 PARG (0.58) PARG
SCHEMBL31121989 0.77 PARG (1.00) PARG
SCHEMBL17845428 0.77 PARG (1.00) PARG
SCHEMBL17863666 0.77 PARG (1.00) PARG
SCHEMBL17845433 0.76 PARG (0.57) PARG
SCHEMBL17845559 0.76 PARG (1.00) PARG
SCHEMBL17845267 0.75 PARG (1.00) PARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3233845-A1 PARG INHIBITORY COMPOUNDS Cancer Research Technology Limited (GB) 2017-10-25 EP disclosed
WO-2016097749-A1 PARG INHIBITORY COMPOUNDS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2016-06-23 WO disclosed