SCHEMBL17845709

SCHEMBL17845709

NS(=O)(=O)c1ccc2c(c1)n(-c1nnc(C(F)F)o1)c(=O)n2CC1(CF)CC1

nearest known ligand 0.62

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PARG Q86W56 20/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17845682 0.80 PARG (0.58) PARG
SCHEMBL17845402 0.77 PARG (0.57) PARG
SCHEMBL17845529 0.74 PARG (1.00) PARG
SCHEMBL17845305 0.73 PARG (1.00) PARG
SCHEMBL17845410 0.73 PARG (0.65) PARG
SCHEMBL17845584 0.69 PARG (1.00) PARG
SCHEMBL17845504 0.67 PARG (0.58) PARG
SCHEMBL28526083 0.65 PARG (0.57) PARG
SCHEMBL17845450 0.65 PARG (0.62) PARG
SCHEMBL17845395 0.64 PARG (0.57) PARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3233845-A1 PARG INHIBITORY COMPOUNDS Cancer Research Technology Limited (GB) 2017-10-25 EP disclosed
WO-2016097749-A1 PARG INHIBITORY COMPOUNDS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2016-06-23 WO disclosed