Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177744 | 0.98 | — | — | |
| SCHEMBL30736102 | 0.98 | — | — | |
| Iodide SCHEMBL28203944 | 0.95 | ALDH1A1 (0.59) | ALDH1A1KDM4ECES2CES1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4201173 | 0.95 | ALDH1A1 (0.59) | ALDH1A1KDM4ECES2CES1L3MBTL1 | |
| SCHEMBL27996729 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KDM4ECES2CES1L3MBTL1 | |
| SCHEMBL19857098 | 0.83 | ALDH1A1 (0.47) | ALDH1A1KDM4ECES2CES1L3MBTL1 | |
| SCHEMBL11761341 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4ECES2CES1L3MBTL1 | |
| Methyl Alcohol SCHEMBL28478481 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4ECES2CES1L3MBTL1 | |
| SCHEMBL11646818 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KDM4ECES2CES1L3MBTL1 | |
| SCHEMBL15527129 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108291911-A | REAGENT AND METHOD FOR MEASURING THROMBIN-ANTITHROMBIN COMPLEX | 美迪恩斯生命科技株式会社 | 2018-07-17 | — | — | CN | claimed |
| US-10975525-B2 | Finely divided, cationic, aqueous polymer dispersions, method for the production thereof, and the use thereof | SOLENIS TECHNOLOGIES, L.P. (US) | 2021-04-13 | — | — | US | disclosed |
| EP-3383929-B1 | FINELY DIVIDED, CATIONIC, AQUEOUS POLYMER DISPERSIONS, METHOD FOR THE PRODUCTION THEREOF, AND THE USE THEREOF | SOLENIS TECHNOLOGIES CAYMAN LP (KY) | 2020-11-04 | — | — | EP | disclosed |
| US-20180355558-A1 | FINELY DIVIDED, CATIONIC, AQUEOUS POLYMER DISPERSIONS, METHOD FOR THE PRODUCTION THEREOF, AND THE USE THEREOF | BASF SE (DE) | 2018-12-13 | — | — | US | disclosed |
| EP-3383929-A1 | FINELY DIVIDED, CATIONIC, AQUEOUS POLYMER DISPERSIONS, METHOD FOR THE PRODUCTION THEREOF, AND THE USE THEREOF | BASF SE (DE) | 2018-10-10 | — | — | EP | disclosed |
| CN-108291911-A | REAGENT AND METHOD FOR MEASURING THROMBIN-ANTITHROMBIN COMPLEX | 美迪恩斯生命科技株式会社 | 2018-07-17 | — | — | CN | disclosed |
| US-20170369604-A1 | FINELY DIVIDED, CATIONIC, AQUEOUS POLYMER DISPERSIONS, METHOD FOR THE PRODUCTION THEREOF, AND THE USE THEREOF | BASF SE (DE) | 2017-12-28 | — | — | US | disclosed |
| EP-3233931-A1 | FINELY DIVIDED, CATIONIC, AQUEOUS POLYMER DISPERSIONS, METHOD FOR THE PRODUCTION THEREOF, AND THE USE THEREOF | BASF SE (DE) | 2017-10-25 | — | — | EP | disclosed |
| WO-2017093368-A1 | FINELY DIVIDED, CATIONIC, AQUEOUS POLYMER DISPERSIONS, METHOD FOR THE PRODUCTION THEREOF, AND THE USE THEREOF | BASF SE (DE) | 2017-06-08 | — | — | WO | disclosed |
| WO-2016098006-A1 | FINELY DIVIDED, CATIONIC, AQUEOUS POLYMER DISPERSIONS, METHOD FOR THE PRODUCTION THEREOF, AND THE USE THEREOF | BASF SE (DE) | 2016-06-23 | — | — | WO | disclosed |