Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.41 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | SCN4A | P35499 | 3/20 | 0.34 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204244 | 1.00 | MAPK1 (0.41) | MAPK1TACR1SCN4ABCDIN3DHASPIN | |
| SCHEMBL19348964 | 0.86 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL20204242 | 0.86 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL17846021 | 0.86 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL20204246 | 0.85 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL17846153 | 0.85 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL17846128 | 0.85 | HTR2A (0.36) | MAPK1 | |
| SCHEMBL17846047 | 0.85 | HTR2A (0.36) | MAPK1 | |
| SCHEMBL17846016 | 0.83 | MAPK1 (0.39) | MAPK1TACR1SCN4ABCDIN3DHASPIN | |
| SCHEMBL20204247 | 0.80 | MAPK1 (0.43) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-B1 | BRIDGED PYRAZOLOPYRIDINE DERIVATIVES AS ERK INHIBITORS USEFUL FOR THE TREATEMENT OF CANCER | MERCK SHARP & DOHME (US) | 2019-08-07 | — | — | EP | disclosed |
| US-9988397-B2 | ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-06-05 | — | — | US | disclosed |
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |