Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 20/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204245 | 1.00 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL20204246 | 1.00 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL20204242 | 0.93 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL17846021 | 0.93 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL17846110 | 0.86 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL20204244 | 0.85 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL17846151 | 0.85 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL19348964 | 0.83 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL19350254 | 0.81 | GPR139 (0.35) | MAPK1 | |
| SCHEMBL17846183 | 0.81 | MAPK1 (0.42) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |