SCHEMBL1784677

SCHEMBL1784677

CC1(OC(=O)c2ccccc2)C=CC(C)(OC(=O)c2ccccc2)C=C1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.54
LMNA P02545 2/20 0.52
F2 P00734 1/20 0.52
TDP1 Q9NUW8 4/20 0.46
ALDH1A1 P00352 4/20 0.46
HSD17B10 Q99714 1/20 0.46
GAA P10253 1/20 0.45
TP53 P04637 1/20 0.44
KMT2A Q03164 5/20 0.42
MAPK1 P28482 2/20 0.42
MEN1 O00255 1/20 0.42
MAPT P10636 4/20 0.42
HIF1A Q16665 1/20 0.42
POLB P06746 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A3 Q01959 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
DAO P14920 1/20 0.41
NAPRT Q6XQN6 1/20 0.41
CES2 O00748 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16861396 0.78 TSHR (0.52) TSHRLMNAF2TDP1ALDH1A1
SCHEMBL27481781 0.78 TSHR (0.52) TSHRLMNAF2TDP1ALDH1A1
SCHEMBL13561708 0.75 TSHR (0.48) TSHRLMNAF2TDP1ALDH1A1
SCHEMBL29941836 0.75 TSHR (0.48) TSHRLMNAF2TDP1ALDH1A1
SCHEMBL6068257 0.74 CYP17A1 (0.49) TSHRLMNAF2TDP1GAA
SCHEMBL18543882 0.73 TSHR (0.43) TSHRLMNAF2TDP1ALDH1A1
SCHEMBL13564220 0.73 TSHR (0.47) TSHRLMNAF2TDP1ALDH1A1
SCHEMBL38660477 0.73 TSHR (0.47) TSHRLMNAF2TDP1ALDH1A1
SCHEMBL1822836 0.70 LMNA (0.64) TSHRLMNAF2TDP1ALDH1A1
Methyl Alcohol SCHEMBL19514313 0.70 TSHR (0.65) TSHRLMNAF2TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1472293-B1 SOLID CATALYST COMPONENT FOR POLYMERIZATION OF OLEFINS, CATALYST COMPRISING THE SAME AND USE THEREOF CHINA PETROLEUM & CHEM CORP (CN) 2017-04-26 EP claimed
US-7388061-B2 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-06-17 US claimed
US-20050239636-A1 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2005-10-27 US claimed
EP-3486263-A2 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE W.R. Grace & CO. - CONN. (US) 2019-05-22 EP disclosed
EP-2185600-B1 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE GRACE W R & CO (US) 2018-10-31 EP disclosed
US-9796796-B2 Self-limiting catalyst composition with No silane W. R. GRACE & CO.-CONN. (US) 2017-10-24 US disclosed
EP-1472293-B1 SOLID CATALYST COMPONENT FOR POLYMERIZATION OF OLEFINS, CATALYST COMPRISING THE SAME AND USE THEREOF CHINA PETROLEUM & CHEM CORP (CN) 2017-04-26 EP disclosed
US-20130109789-A1 OLEFIN POLYMERIZATION CATALYST, PROCESS FOR PRODUCING OLEFIN POLYMER, POLYPROPYLENE RESIN COMPOSITION AND ARTICLE COMPRISING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-02 US disclosed
US-20110124491-A1 Self-Limiting Catalyst Composition with No Silane W. R. GRACE & CO.-CONN. 2011-05-26 US disclosed
EP-2185600-A1 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE Dow Global Technologies Inc. (US) 2010-05-19 EP disclosed
WO-2009029447-A1 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE DOW GLOBAL TECHNOLOGIES INC. (US) 2009-03-05 WO disclosed
US-7388061-B2 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-06-17 US disclosed
US-20050239636-A1 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2005-10-27 US disclosed