⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696483 | 0.79 | — | — | |
| SCHEMBL1783370 | 0.75 | P2RY6 (0.38) | — | |
| SCHEMBL3701530 | 0.73 | — | — | |
| SCHEMBL15884464 | 0.71 | — | — | |
| SCHEMBL3683850 | 0.71 | — | — | |
| SCHEMBL13049181 | 0.71 | P2RY6 (0.34) | — | |
| SCHEMBL21241319 | 0.68 | ALDH1A1 (0.33) | — | |
| SCHEMBL31010438 | 0.67 | — | — | |
| SCHEMBL21406506 | 0.66 | MIF (0.47) | — | |
| SCHEMBL22637570 | 0.65 | ALDH1A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139286-B1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AG (DE) | 2025-02-26 | — | — | EP | disclosed |
| US-12018021-B2 | Thiophene derivatives for the treatment of disorders caused by IgE | UCB Biopharma SRL (BE) | 2024-06-25 | — | — | US | disclosed |
| US-11964953-B2 | Substituted aminothiazoles as DGKzeta inhibitors for immune activation | BAYER AKTIENGESELLSCHAFT (DE) | 2024-04-23 | — | — | US | disclosed |
| US-20230167078-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2023-06-01 | — | — | US | disclosed |
| US-20230139936-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2023-05-04 | — | — | US | disclosed |
| WO-2023039828-A1 | FUSED RING COMPOUNDS AS INHIBITORS OF FGFR4 TYROSINE KINASES | NUTSHELL BIOTECH (SHANGHAI) CO., LTD. (CN) | 2023-03-23 | — | — | WO | disclosed |
| US-20220332709-A1 | Thiophene derivatives for the treatment of disorders caused by IgE | UCB Biopharma SRL (BE) | 2022-10-20 | — | — | US | disclosed |
| WO-2022194273-A1 | FUSED RING COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | NUTSHELL BIOTECH (SHANGHAI) CO., LTD. (CN) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022193227-A1 | FUSED RING COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | NUTSHELL BIOTECH (SHANGHAI) CO., LTD. (CN) | 2022-09-22 | — | — | WO | disclosed |
| EP-3810606-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2021-04-28 | — | — | EP | disclosed |
| US-20130018072-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-17 | — | — | US | disclosed |
| US-8269012-B2 | Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-8269012-B2 | Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-8269012-B2 | Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| EP-2435443-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | Vertex Pharmaceuticals Incorporated (US) | 2012-04-04 | — | — | EP | disclosed |
| US-20110124684-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-26 | — | — | US | disclosed |
| US-20110124684-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-26 | — | — | US | disclosed |
| US-20110124684-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-26 | — | — | US | disclosed |
| WO-2010138665-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138665-A1 | AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-02 | — | — | WO | disclosed |