Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 11/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PRKACA | P17612 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848108 | 0.88 | MAPK1 (0.47) | JAK2PDPK1NTRK1MKNK2MAPK1 | |
| SCHEMBL17848143 | 0.76 | FGFR1 (0.43) | JAK2PDPK1NTRK1MKNK2MKNK1 | |
| SCHEMBL17848223 | 0.75 | NTRK1 (0.51) | NTRK1GSK3BAURKBPLK4DAPK3 | |
| SCHEMBL30451203 | 0.75 | NTRK1 (0.66) | JAK2PDPK1NTRK1AURKB | |
| SCHEMBL3510229 | 0.75 | NTRK1 (0.66) | JAK2PDPK1NTRK1AURKB | |
| SCHEMBL17848137 | 0.72 | MAPK1 (0.37) | JAK2NTRK1MKNK2MAPK1MKNK1 | |
| SCHEMBL6478729 | 0.72 | PDPK1 (0.59) | JAK2PDPK1CDK2GSK3BAURKB | |
| SCHEMBL29415511 | 0.67 | NTRK1 (0.52) | JAK2PDPK1NTRK1MKNK2MAPK1 | |
| SCHEMBL29415512 | 0.67 | NTRK1 (0.52) | JAK2PDPK1NTRK1MKNK2MAPK1 | |
| SCHEMBL3512493 | 0.67 | NTRK1 (0.52) | JAK2PDPK1NTRK1MKNK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | EUDENDRON S.R.L. (IT) | 2019-07-02 | — | — | US | disclosed |
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | EUDENDRON S.R.L. (IT) | 2019-07-02 | — | — | US | disclosed |
| EP-3233840-B1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S R L (IT) | 2018-11-21 | — | — | EP | disclosed |
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | MAP4K2, MAP3K20, MAPKAPK2 | JAK2 394/4885PDPK1 46/4885NTRK1 561/4885 |
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | MAP4K2, MAP3K20, MAPKAPK2 | JAK2 394/4885PDPK1 46/4885NTRK1 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.