Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 19/20 | 0.84 |
| ▸ | FXR2 | P51116 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10263154 | 1.00 | NR1H4 (0.84) | NR1H4FXR2 | |
| SCHEMBL17145988 | 1.00 | NR1H4 (0.84) | NR1H4FXR2 | |
| SCHEMBL17145987 | 0.94 | NR1H4 (0.81) | NR1H4 | |
| SCHEMBL9955743 | 0.94 | NR1H4 (0.81) | NR1H4 | |
| SCHEMBL20833699 | 0.93 | NR1H4 (0.74) | NR1H4FXR2 | |
| SCHEMBL17128505 | 0.92 | NR1H4 (1.00) | NR1H4FXR2 | |
| SCHEMBL17128508 | 0.92 | NR1H4 (1.00) | NR1H4FXR2 | |
| SCHEMBL9958227 | 0.92 | NR1H4 (1.00) | NR1H4FXR2 | |
| SCHEMBL19739533 | 0.92 | NR1H4 (1.00) | NR1H4FXR2 | |
| SCHEMBL17861443 | 0.92 | NR1H4 (1.00) | NR1H4FXR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233083-A1 | AZABICYCLOOCTANE DERIVATIVES AS FXR AGONISTS FOR USE IN THE TREATMENT OF LIVER AND GASTROINTESTINAL DISEASES | Novartis AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097933-A1 | AZABICYCLOOCTANE DERIVATIVES AS FXR AGONISTS FOR USE IN THE TREATMENT OF LIVER AND GASTROINTESTINAL DISEASES | NOVARTIS AG (CH) | 2016-06-23 | — | — | WO | disclosed |